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Food science and biotechnology v.21 no.2, 2012년, pp.559 - 564   SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Effect of Oral Administration of Nutmeg Extract on American House Dust Mite (Dermatophagoides farinae) Extract-induced Atopic Dermatitis-like Skin Lesions in NC/Nga Mice

Chung, Hee-Chul    (Department of Biomaterials Science and Engineering, Yonsei University   ); Kim, Myung-Suk    (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University   ); Mun, Suk-Yeong    (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University   ); Sa, Bo-Kyung    (Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University   ); Chung, Jae-Yoon    (Newtree Co., Ltd.   ); Kim, Do-Un    (Newtree Co., Ltd.   ); Hwang, Jae-Kwan    (Department of Biomaterials Science and Engineering, Yonsei University  );
  • 초록

    The effects of oral administration of nutmeg extract (NE) on atopic dermatitis (AD) were evaluated using NC/Nga mice treated with American house dust mite (Dermatophagoides farinae) extract. In this mouse model of AD, NE suppressed transepidermal water loss, erythema, and the production of serum immunoglobulin E, interleukin (IL)-4, and interferon- ${\gamma}$ by auxillary lymph node cells. In addition, NE reduced epidermal thickening and inflammatory cell infiltration into the skin. In skin lesions, NE suppressed IL-13 and tumor necrosis factor (TNF)- ${\alpha}$ mRNA expression. In the spleen, NE upregulated T-box transcription factor expressed in T cells and downregulated GATA-binding protein 3, which are involved in T helper cell differentiation. Our findings suggest that NE ameliorates AD and may be a potential nutraceutical candidate for treating AD.


  • 주제어

    nutmeg (Myristica fragrans Houtt) .   atopic dermatitis .   Dermatophagoides farinae extract .   NC/Nga mice.  

  • 참고문헌 (17)

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