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구속 스트레스 쥐 모델에서 스트레스 반응 감소에 대한 사카린 섭취의 효과
Effect of Saccharin Intake in Restraint-induced Stress Response Reduction in Rats

박종민   (경북보건대학교 간호학과UU0000098  ); 송민경   (경희대학교 간호과학대학UU0001575  ); 김윤주   (경희대학교 간호과학대학UU0001575  ); 김연정   (경희대학교 간호과학대학.동서간호학 연구소UU0001575  );
  • 초록

    Purpose: Stress activates the sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis and induces the release of glucocorticoids. Saccharin is 300 times sweeter than sucrose, but does not increase blood insulin levels. Thus, this study was designed to evaluate the effect of saccharin intake in restraint-induced stress response reduction in rats. Methods: Adult male Sprague-Dawley (SD) rats had stress induced by restraint for 2 hours/day for 1 week. Saccharin was provided in sufficient amounts to allow them to intake it voluntarily at 0.1% diluted in water. The Y-maze test and forced swim test (FST) were performed to evaluate cognitive function and the depressive behavior of the rats. The protein expression of the glucocorticoid receptor (GR) in hippocampal cornu ammonis (CA) 1 was investigated by using immunohistochemistry. Results: It was found that, the percentage of alternation in the Y-maze test was significantly (p


  • 주제어

    스트레스 .   사카린 .   글루코코르티코이드 수용체.  

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