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Comparative evaluation of the efficacy, safety, and hemostatic effect of 2% lidocaine with various concentrations of epinephrine

Karm, Myong-Hwan   (Department of Dental Anesthesiology, Seoul National University Dental Hospital  ); Kim, Minyoung   (Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University  ); Park, Fiona D.   (Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University  ); Seo, Kwang-Suk   (Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University  ); Kim, Hyun Jeong   (Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University  );
  • 초록

    Background: We evaluated the changes in mean arterial pressure (MAP) and heart rate (HR), and the anesthetic and hemostatic effects, after injection of 2% lidocaine containing various concentrations of epinephrine in rats and mice to determine the appropriate concentration of epinephrine in various anesthetic mixtures. Methods: Rats and mice were randomly allocated to experimental groups: 2% lidocaine without epinephrine (L0), 2% lidocaine with epinephrine 1:200,000 (L200), 1:100,000 (L100), and 1:80,000 (L80). Changes in MAP and HR after administration of the anesthetic mixture were evaluated using a physiological recording system in rats. Onset and duration of local anesthesia was evaluated by pricking the hind paw of mice. A spectrophotometric hemoglobin assay was used to quantify the hemostatic effect. Results: MAP increased in response to epinephrine in a dose-dependent manner; it was significantly higher in the L80 group than in the L0 group at 5 min post-administration. The HR was relatively lower in the L0 group than in the L80 group. The time required for onset of action was


  • 주제어

    Arterial Pressure  . Epinephrine  . Hemostasis  . Lidocaine  . Local Anesthetics  .

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