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Pediatric gastroenterology, hepatology & nutrition v.21 no.3, 2018년, pp.176 - 183   KCI
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Surveillance Study of Acute Gastroenteritis Etiologies in Hospitalized Children in South Lebanon (SAGE study)

Ghssein, Ghassan   (Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) Research Group, Lebanese University, Faculty of Sciences (V)  ); Salami, Ali   (Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) Research Group, Lebanese University, Faculty of Sciences (V)  ); Salloum, Lamis   (Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) Research Group, Lebanese University, Faculty of Sciences (V)  ); Chedid, Pia   (Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Balamand  ); Joumaa, Wissam H   (Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) Research Group, Lebanese University, Faculty of Sciences (V)  ); Fakih, Hadi   (Department of Pediatrics, Faculty of Medical Sciences, Lebanese University  );
  • 초록

    Purpose: Acute gastroenteritis (AGE) is a major cause of morbidity and remains a major cause of hospitalization. Following the Syrian refugee crisis and insufficient clean water in the region, this study reviews the etiological and epidemiological data in Lebanon. Methods: We prospectively analyzed demographic, clinical and routine laboratory data of 198 children from the age of 1 month to 10 years old who were admitted with the diagnosis of AGE to a private tertiary care hospital located in the district of Nabatieh in south Lebanon. Results: Males had a higher incidence of AGE (57.1%). Pathogens were detected in 57.6% (n=114) of admitted patients, among them single pathogens were found in 51.0% (n=101) of cases that consisted of: Entamoeba histolytica 26.3% (n=52), rotavirus 18.7% (n=37), adenovirus 6.1% (n=12) and mixed co-pathogens found in 6.6% (n=13). Breast-fed children were significantly less prone to rotavirus (p=0.041). Moreover, children who had received the rotavirus vaccine were significantly less prone to rotavirus (p=0.032). Conclusion: Our findings highlight the high prevalence of E. histolytica infection as the major cause of pediatric gastroenteritis in hospitalized children, during the summer period likely reflecting the insanitary water supplies and lack of hygiene. Moreover the 42.4% of unidentified causative pathogens should prompt us to widen our diagnostic laboratory arsenal by adopting new diagnostic technologies.


  • 주제어

    Gastroenteritis .   Rotavirus .   Amebiasis .   Diarrhea .   Lebanon.  

  • 참고문헌 (22)

    1. National Institute of Allergy and Infectious Diseases. NIAID emerging infectious diseases/pathogens [Internet]. Bethesda (MD): National Institute of Allergy and Infectious Diseases [cited 2016 Oct 28] Available from: https://www.niaid.nih.gov/research/emerging-infectiousdiseases-pathogens. 
    2. Hegazi MA, Patel TA, El-Deek BS. Prevalence and characters of Entamoeba histolytica infection in Saudi infants and children admitted with diarrhea at 2 main hospitals at South Jeddah: a re-emerging serious infection with unusual presentation. Braz J Infect Dis 2013;17:32-40. 
    3. World Health Organization. Diarrhoeal disease [Internet]. World Health Organization [cited 2017 May]. Available from: http://www.who.int/mediacentre/factsheets/fs330/en/index.html. 
    4. Naous A, Naja Z, Zaatari N, Kamel R, Rajab M. Intestinal amebiasis: a concerning cause of acute gastroenteritis among hospitalized lebanese children. N Am J Med Sci 2013;5:689-98. 
    5. Youssef M, Shurman A, Bougnoux M, Rawashdeh M, Bretagne S, Strockbine N. Bacterial, viral and parasitic enteric pathogens associated with acute diarrhea in hospitalized children from northern Jordan. FEMS Immunol Med Microbiol 2000;28:257-63. 
    6. Mladenova Z, Steyer A, Steyer AF, Ganesh B, Petrov P, Tchervenjakova T, et al. Aetiology of acute paediatric gastroenteritis in Bulgaria during summer months: prevalence of viral infections. J Med Microbiol 2015; 64:272-82. 
    7. Matthys B, Bobieva M, Karimova G, Mengliboeva Z, Jean-Richard V, Hoimnazarova M, et al. Prevalence and risk factors of helminths and intestinal protozoa infections among children from primary schools in western Tajikistan. Parasit Vectors 2011;4:195. 
    8. Stanley SL Jr. Amoebiasis. Lancet 2003;361:1025-34. 
    9. Bern C, Martines J, de Zoysa I, Glass RI. The magnitude of the global problem of diarrhoeal disease: a ten-year update. Bull World Health Organ 1992;70:705-14. 
    10. Chow CM, Leung AK, Hon KL. Acute gastroenteritis: from guidelines to real life. Clin Exp Gastroenterol 2010;3:97-112. 
    11. Buttery JP, Kirkwood C. Rotavirus vaccines in developed countries. Curr Opin Infect Dis 2007;20:253-8. 
    12. Parashar U, Steele D, Neuzil K, Quadros Cd, Tharmaphornpilas P, Serhan F, et al. Progress with rotavirus vaccines: summary of the Tenth International Rotavirus Symposium. Expert Rev Vaccines 2013;12:113-7. 
    13. Kotloff KL, Nataro JP, Blackwelder WC, Nasrin D, Farag TH, Panchalingam S, et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study. Lancet 2013;382:209-22. 
    14. Madhi SA, Cunliffe NA, Steele D, Witte D, Kirsten M, Louw C, et al. Effect of human rotavirus vaccine on severe diarrhea in African infants. N Engl J Med 2010;362:289-98. 
    15. Szajewska H, Dziechciarz P. Gastrointestinal infections in the pediatric population. Curr Opin Gastroenterol 2010;26:36-44. 
    16. Walsh JA. Problems in recognition and diagnosis of amebiasis: estimation of the global magnitude of morbidity and mortality. Rev Infect Dis 1986;8:228-38. 
    17. Ilikkan DY, Ilikkan B, Vural M. Amebiasis in infancy in the middle-high socioeconomic class in Istanbul, Turkey. Pediatr Infect Dis J 2005;24:929-30. 
    18. Dbaibo G, Rajab M, Inati A, Mikhael R, Choueiry E, Al-Tannir M, et al. Hospital-based surveillance study of rotavirus gastroenteritis in children under 5 years of age in Lebanon. Trials Vaccinol 2013;2:25-30. 
    19. Parashar UD, Gibson CJ, Bresee JS, Glass RI. Rotavirus and severe childhood diarrhea. Emerg Infect Dis 2006;12:304-6. 
    20. Nafi O. Rotavirus gastroenteritis among children aged under 5 years in Al Karak, Jordan. East Mediterr Health J 2010;16:1064-9. 
    21. Wood DJ. Adenovirus gastroenteritis. Br Med J (Clin Res Ed) 1988;296:229-30. 
    22. Ali Z, Harastani H, Hammadi M, Reslan L, Ghanem S, Hajar F, et al. Rotavirus genotypes and vaccine effectiveness from a sentinel, hospital-based, surveillance study for three consecutive rotavirus seasons in lebanon. PLoS One 2016;11:e0161345. 

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