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논문 상세정보

대한임상독성학회지 = Journal of the Korean Society of Clinical Toxicology   v.16 no.1, 2018년, pp.42 - 48   KCI후보
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

안전상비의약품 판매 이후 중독환자 특성 변화
Changes in Toxicological Characteristics after Sales of Nonprescription Drugs in Convenience Stores

김창영   (고려대학교 의과대학 응급의학교실  ); 이의중   (고려대학교 의과대학 응급의학교실  ); 이성우   (고려대학교 의과대학 응급의학교실  ); 김수진   (고려대학교 의과대학 응급의학교실  ); 한갑수   (고려대학교 의과대학 응급의학교실  );
  • 초록

    Purpose: On November 15, 2012, sales of OTC (Over-The-Counter) drugs began at convenience stores, which changed the accessibility of some drugs. As a result, the exposure and access patterns of these drugs could have changed. In this study, we reviewed the changes in the characteristics of drug poisoning patients because of the reposition of nonprescription drugs according to the revised Pharmaceutical Affairs Act. Methods: A retrospective study was conducted to evaluate changes in characteristics of drug poisoning patients between 2008 and 2016. A registry was developed by an emergency medical center in a local tertiary teaching hospital, and patients who visited the center were enrolled in this registry. We compared two periods, from 2008 to 2012 (Pre OTC) and from 2013 to 2016 (Post OTC), for type of intoxicant, time from poisoning to visiting the emergency center, intention, psychiatric history, previous suicidal attempt, alcohol status, and emergency room outcomes. The primary outcome was the number of patients who took acetaminophen and NSAIDs (nonsteroidal anti-inflammatory drugs). Secondary outcomes were ICU admission rate, mortality rate, and number of patients who visited the ER when the pharmacy was closed after taking acetaminophen and NSAIDs (nonsteroidal anti-inflammatory drugs). Results: Among 1,564 patients, 945 and 619 patients visited the emergency room during pre and post OTC periods. The number of patients with acetaminophen and NSAIDs poisoning decreased from 9.2% to 6.1% (p=0.016). The ICU admission rate and mortality rate in the emergency room did not show significant results in the relevant patient groups, and so was the number of patients visiting ER when the pharmacy was closed taking acetaminophen and NSAIDs. Conclusion: Despite the sales of nonprescription drugs at convenience stores, the number of acetaminophen and NSAIDs poisoning patients decreased.


  • 주제어

    Poisoning  . Nonprescription drugs  . Acetaminophen  . Anti-inflammatory agents  . Non-steroidal  .

  • 참고문헌 (12)

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    7. Cha ES, Chang SS, Gunnell D, Eddleston M, Khang YH, Lee WJ. Impact of paraquat regulation on suicide in South Korea. Int J Epidemiol 2016;45:470-9. 
    8. Kong SK, Oh SH, Park KN, Kim HJ. Kim HJ. Trends of Intentional Poisoning: A Retrospective Single Center Study During 15 Years. Journal of The Korean Society of Clinical Toxicology 2016;14:47-53. 
    9. Health Insurance Review & Assessment Servic. Healthcare Bigdata Hub. Available from: http://opendata.hira.or.kr/op/opc/olapDiagTpInfo.do Accessed 2 May, 2018. 
    10. Lee JH, Sang Oh H, Park KN, Youn CS, Kim SH, Jeong WJ et al. Epidemiologic Study of Poisoned Patients Who Presented to the Emergency Department of a High end Medical Facility in Seoul 1998-2009. Journal of The Korean Society of Clinical Toxicology 2010;8:7-15. 
    11. Lee HS, Han JH, Kim JH, Kim SP, Kim SH, Lee JS, et al. Epidemiologic Characteristics of Intentional Poisoning: Emergency Department Based Injury in-depth Surveillance During 2011-2015. Journal of The Korean Society of Clinical Toxicology 2017;15:131-9. 
    12. Park KH, Park JS, Lee SW, Kim SJ, Han KS, Lee EJ: Changes of Poison Data Characteristics Collected from Telephone Response in 1339 and 119: Discrepancy in Characteristics of Post-toxin Exposure Data Obtained through Telephone Counselling Provided by 1339 and 119. Journal of The Korean Society of Clinical Toxicology 2017;15:116-21. 

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