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韓國家畜衛生學會誌 = Korean journal of veterinary service v.41 no.2, 2018년, pp.79 - 83   KCI
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Evaluation of ST2 and NT-proBNP as cardiac biomarkers in dogs with heartworm disease

Lee, Kiho   (College of Veterinary Medicine, Chungnam National University  ); Park, Jun-Seok   (College of Veterinary Medicine, Chungnam National University  ); Seo, Kyoung-Won   (College of Veterinary Medicine, Chungnam National University  ); Song, Kun-Ho   (College of Veterinary Medicine, Chungnam National University  );
  • 초록

    This study compared serum concentrations of suppression of tumorigenicity 2 (ST2) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) between healthy and heartworm- infected dogs. Eighteen heartworm-infected dogs and five healthy dogs were included in the study. Dogs were diagnosed and categorized by history, clinical signs, and blood assay, thoracic radiography, echocardiography, and commercial ELISA kit results. Serum samples were sent to the IDEXX reference laboratory for NT-proBNP measurement. ST2 was examined by using a canine interleukin 33 receptor ELISA kit with the quantitative sandwich ELISA method. The severely infected group showed significant elevation of NT-proBNP concentration over those of the control (P=0.03) and mildly infected (P=0.04) group. There were no significant difference in ST2 concentrations among the three groups. The usefulness of NT-proBNP as a cardiac biomarker in dogs with severe heartworm disease was confirmed by the results of this study. Further investigations to assess ST2 as a cardiac biomarker are warranted.


  • 주제어

    ST2 .   NT-proBNP .   Heartworm disease .   Biomarker .   Dog.  

  • 참고문헌 (18)

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    16. Shah RV, Januzzi JL. 2010. ST2: a novel remodeling biomarker in acute and chronic heart failure. Curr Heart Fail Rep 7: 9-14. 
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    18. Villacorta H, Maisel AS. 2016. Soluble ST2 testing: a promising biomarker in the management of heart failure. Arq Bras Cardiol 106: 145-152. 

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