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韓國藥用作物學會誌 = Korean journal of medicinal crop science v.26 no.5, 2018년, pp.417 - 429  
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중합체 매개 용융압출에 의한 참당귀 나노복합체의 제조
Fabrication of Nano-composites from the Radix of Angelica gigas Nakai by Hot Melt Extrusion Mediated Polymer Matrixs

Azad, Md Obyedul Kalam   (Department of Bio-Health Technology, Kangwon National University  ); 조현종    (강원대학교 약학과   ); 임정대    (강원대학교 생약자원개발학과   ); 박철호    (강원대학교 생명건강공학과   ); 강위수    (강원대학교 생명건강공학과  );
  • 초록

    Background: The objective of this study was to make colloidal dispersions of the active compounds of radix of Angelica gigas Nakai that could be charaterized as nano-composites using hot melt extrusion (HME). Food grade hydrophilic polymer matrices were used to disperse these compound in aqueous media. Methods and Results: Extrudate solid formulations (ESFs) mediated by various HPMCs (hydroxypropyl methylcelluloses) and Na-Alg polymers made from ultrafine powder of the radix of Angelica gigas Nakai were developed through a physical crosslink method (HME) using an ionization agent (treatment with acetic acid) and different food grade polymers [HPMCs, such as HP55, CN40H, AN6 and sodium alignate (Na-Alg)]. X-ray powder diffraction (XRD) analysis confirmed the amorphization of crystal compounds in the HP55-mediated extrudate solid formulation (HP55-ESF). Differential scanning calorimetry (DSC) analysis indicated a lower enthalpy ( ${\Delta}H=10.62J/g$ ) of glass transition temperature (Tg) in the HP55-ESF than in the other formulations. Infrared fourier transform spectroscopy (FT-IR) revealed that new functional groups were produced in the HP55-ESF. The content of phenolic compounds, flavonoid (including decursin and decursinol angelate) content, and antioxidant activity increased by 5, 10, and 2 times in the HP55-ESF, respectively. The production of water soluble (61.5%) nano-sized (323 nm) particles was achieved in the HP55-ESF. Conclusions: Nano-composites were developed herein utilizing melt-extruded solid dispersion technology, including food grade polymer enhanced nano dispersion (


  • 주제어

    Angelica gigas Nakai .   Food Grade Polymer .   Hot Melt Extrusion .   Nano-composite .   Solid Formulation.  

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