Proteoglycan Alterations in the Aortic Intima-Media of Alloxan-Diabetic Rabbits: An Ultrastructural and Biochemical Study
Proteoglycans and glycosaminoglycans in the aortic intima of diabetic rabbits and age-matched controls were examined at 2 weeks and 3, 6, and 12 months after alloxan (or saline) treatment. Measurements were made by morphometric analysis of ruthenium red-stained large proteoglycan granules (LPG) in electron micrographs and by analysis of 35 S-labeled glycosaminoglycans, extracted and purified from the intima-media of aortas of rabbits which had been injected with 35 S-sulfate 18 hr before exsanguination. There was a progressive increase in the area of the aortic intima with time which was greater in diabetic than in control rabbits. The concentration of proteoglycan (LPG/μm 2 ) and the concentration of the 35 S-glycosaminoglycans in diabetic intima-media were similar to respective values of control intima-media throughout the 12 months. However, the specific radioactivity of the [ 35 S]glycosaminoglycan pool from intima-media of diabetic rabbits was significantly less than that from controls (P
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