본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Experimental and molecular pathology v.62 no.3, 1995년, pp.180 - 189  

Localization of Retinoic Acid Receptors in Anterior Human Embryo

Sharma, R.P. ; Kim, Y.W. ;
  • 초록  

    Retinoic acid receptors (RARs) are nuclear transcription factors that are activated by all-trans-retinoic acid or 9-cis-retinoic acid and are found in all tissues but predominantly in developing fetus, dividing tumor cells, and adult skin. Three forms of these receptors, α, β, and γ, have been described. In this paper we report the presence of RARα and β determined by hybridization with anti-sense messenger RNA, and histochemical localization of the three forms of RARs using monospecific polyclonal antibodies in various tissues of early human embryos. In a 54-day-old embryo, RARα was expressed primarily in the liver and the brain, with somewhat lesser expression in the intestine. RARβ was the highest in the brain, followed by a restricted expression in the intestine and the liver. Other organs, i.e., adrenal, kidney, and testis, did not show measurable amounts of RARβ. The immunohistochemical localization in anterior sections of a 43-day-old embryo indicated that RARα was present in the neuroepithelial cells and in cells lining the primitive pharyngeal sac, dorsal aorta, and pericardium. RARβ was somewhat less prevalent in same tissues, whereas the expression of RARγ was the lowest of the tree RARs in any tissues examined. Results indicated that RARα and β appear at early stages of human embryonic development and their expression is restricted to certain types of tissues.


  • 원문보기

    원문보기
    무료다운로드 유료다운로드
    • 무료 원문 정보가 존재하지 않습니다.

    유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역