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Neuroscience letters v.209 no.1, 1996년, pp.41 - 44  

The 5-HT1A agonist ipsapirone enhances EEG slow wave activity in human sleep and produces a power spectrum similar to 5-HT2 blockade

Seifritz, Erich ; Moore, Polly ; Trachsel, Lorenz ; Bhatti, Tahir ; Stahl, Stephen M. ; Gillin, J.Christian ;
  • 초록  

    Abstract The REM sleep-suppressing effect of postsynaptic 5-HT 1A stimulation has been well established. Here we investigate the effects of the 5-HT 1A agonist ipsapirone (10 and 20 mg) on sleep EEG power spectra during non-REM sleep in nine healthy humans. At the lower dose, slow wave activity (SWA; EEG power in the δ (1–4.5 Hz) range) was significantly enhanced. At the higher dose, where side-effects occurred, the enhancement in SWA was not significant. The spectral profile was characterized by a bimodal increase of power in the lower δ and in the θ (5–8 Hz) frequencies, and by troughs at 4 Hz and at 11 Hz, a pattern compellingly similar to that reported for a 5-HT 2 antagonists (seganserin). We propose that the spectral data following the lower ipsapirone dose reflect a net decrease of neuronal activity at 5-HT 2 receptors, mediated through stimulation of somatodendritic autoreceptors in the raphe nuclei (presynaptic) and/or through stimulation of postsynaptic 5-HT 1A receptors colocalized with 5-HT 2 receptors. The spectral non-REM sleep EEG profile might be used to investigate central 5-HT function in humans.


  • 주제어

    Serotonin .   5-HT1A receptor .   5-HT2A receptor .   Sleep EEG .   Human slow wave sleep .   Spectral analysis .   Ipsapirone .   Seganserin.  

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