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Neuroscience letters v.209 no.1, 1996년, pp.65 - 68  

Rapid but transient increases in cholecystokinin mRNA levels in cerebral cortex following amygdaloid-kindled seizures in the rat

Burazin, Tanya C.D. ; Gundlach, Andrew L. ;
  • 초록  

    Abstract Cholecystokinin-octapeptide (CCK-8S) is widely distributed in neurones of the central nervous system, where it is thought to act as a transmitter or modulator. CCK-8S has been shown to exert anti-convulsant activity in animal seizure models and changes in cortical and hippocampal CCK-immunoreactivity and preproCCK messenger RNA (mRNA) have been reported following electrically- and chemically-induced seizures. In the present study, the spatiotemporal effect of amygdaloid-kindled seizures on levels of preproCCK messenger RNA in rat brain were determined using quantitative in situ hybridization histochemistry. Stimulation-evoked seizures produced bilateral increases (45–70%) in preproCCK mRNA throughout layers II–III of the cerebral cortex. These increases were rapidly induced, occurring 30–60 min after the last stage 5 seizure, but transient, as no significant changes were detected after 2 h, or subsequently at 24 or 72 h, or 2–8 weeks, post-stimulation. Rapid changes in the relative levels of preproCCK mRNA, post-seizure, suggest a possible stabilization of preproCCK transcripts and increased production of CCK-8S peptide, which may be involved in anti-convulsant mechanisms in response to the acute seizures.


  • 주제어

    Cholecystokinin .   Messenger RNA .   In situ hybridization histochemistry .   Cerebral cortex .   Amygdaloid kindling .   Seizures .   Epilepsy.  

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