Correlation of the polysaccharide antigens of Francisella tularensis with virulence in experimental mice.
Francisella tularensis gives rise to two distinct colony types, acriflavine agglutination test-positive (acf+) and -negative (acf-) colonies. The acf+ variants were exclusively low virulent in mice, while the acf- variants were shown to be either high or low virulent. Three fractions, phosphate-buffered saline-extractable without heating, with heating at 60 C, and with heating at 100 C, were obtained from cultures of both the acf+ and acf- variants on agar media, and the polysaccharide antigens in those fractions were quantitated. All of the highly virulent acf- variants possessed a large amount of the polysaccharide antigen in the fraction extractable with heating at 60 C. This antigen was not, however, detected in any of the acf+ variants and one low-virulent acf- variant. It was also detected in a very low amount in some other acf- variants with low virulence. The amount of this polysaccharide antigen was therefore shown to be correlated with bacterial virulence in mice.
- Japan Science and Technology Information Aggregator, Electronic : 저널> 권호 > http://www.jstage.jst.go.jp/article/mandi1977/39/12/39_12_1007/_article
- Blackwell Publishing_STM : 저널
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