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FEBS letters v.385 no.3, 1996년, pp.233 - 237  

Glucose catabolism in cancer cells: regulation of the type II hexokinase promoter by glucose and cyclic AMP

Rempel, Annette (Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205-2185, USA ); Mathupala, Saroj P. ( Department of Biological Chemistry, The Johns Hopkins University, School of Medicine, Baltimore, MD 21205-2185, USA ); Pedersen, Peter L. ( Corresponding author. Fax: (1) (410) 614-1944. );
  • 초록  

    Abstract The increased glucose consumption of many tumor cells depends to a large extent on the overexpression of hexokinase Type II. In a previous study we isolated and sequenced the hepatoma Type II hexokinase promoter and showed that it is activated by glucose in the highly glycolytic AS-30D hepatoma cell line under study, but not activated in control hepatocytes [Mathupala, S.P., Rempel, A. and Pedersen, P.L. (1995) J. Biol. Chem. 270, 16918–16925]. Here we report that the promoter of the hexokinase Type II gene is maximally activated by glucose at concentrations above 5 mM. Moreover, the data strongly suggest that glucose can act alone without requirement for metabolism. Also, glucose-mediated promoter activation is markedly potentiated by cAMP. This response may serve as a strategy for cancer cells to maintain the hexokinase transcription rate high to ensure an efficient glucose utilization even under conditions where carbohydrates are limiting.


  • 주제어

    Cancer .   Type II hexokinase .   Glucose catabolism .   Cyclic AMP .   Protein kinase A .   Gene regulation.  

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