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European journal of pharmacology v.300 no.3, 1996년, pp.221 - 225  

Contractile responses of human deferential artery and vas deferens to vasopressin

Medina, P. ; Martí ; nez, M.C. ; Aldasoro, M. ; Vila, J.M. ; Chuan, P. ; Lluch, S. ;
  • 초록  

    Abstract We studied the effects of vasopressin on isolated rings of human deferential artery and vas deferens (prostatic portion) obtained from patients undergoing radical cystectomy ( n = 11) or prostatectomy ( n = 10). Ring segments of artery or vas deferens were studied in organ bath experiments at optimal resting tension. In artery rings, vasopressin produced concentration-dependent, endothelium-independent contractions with an EC 50 of 4.5 × 10 −10 M. The presence of N G -nitro- L -arginine methyl ester hydrochloride (10 −4 M), an inhibitor of nitric oxide synthase, did not change significantly ( P > 0.05) the vasopressin-induced contraction. In ring preparations of the prostatic part of the vas deferens, vasopressin induced phasic contractions with an EC 50 of 7.0 × 10 −9 M. The vasopressin V 1 receptor antagonist, d(CH 2 ) 5 Tyr(Me)AVP (10 −8 and 10 −6 ), displaced to the right in parallel the control curve to vasopressin in artery and vas deferens rings. These results indicate that vasopressin exerts a powerful constrictor action on human deferential artery and vas deferens by direct stimulation of V 1 receptors. It is concluded that the deferential artery may dampen the passage of blood to the vas deferens in circumstances characterized by increased plasma vasopressin levels.


  • 주제어

    Deferential artery, human .   Vas deferens .   Vasopressin .   Endothelium .   Nitric oxide (NO).  

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