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Neuropharmacology v.32 no.3, 1993년, pp.217 - 221  

Social interaction and elevated plus-maze tests: Changes in release and uptake of 5-HT and GABA

File, S.E. ; Zangrossi, H. ; Andrews, N. ;
  • 초록  

    Changes in release and uptake of [ 3 H]5-HT and [ 14 C]GABA were compared in slices taken from the hippocampus and frontal cortex of rats, left undisturbed in their home-cages, or exposed for 5 min to the elevated plus-maze or social interaction tests of anxiety. Exposure to the plus-maze decreased cortical GABA function (shown by decreased release) and increased hippocampal 5-HT function (shown by increased K + -evoked release but more markedly by decreased uptake). Compared with undisturbed home cage controls, only the high light, familiar condition of the social interaction test resulted in a significant increase in K + -evoked release of both [ 3 H]5-HT and [ 14 C]GABA from the hippocampus. All four social interaction test conditions resulted in increases in cortical uptake of [ 3 H]5-HT and all but the high light, unfamiliar condition increased cortical uptake of [ 14 C]GABA. Analysing the two factors manipulated in the social interaction test, unfamiliarity with the test arena resulted in increased uptake of hippocampal [ 3 H]5-HT and decreased cortical [ 14 C]GABA, whereas an increase in the level of light decreased the cortical uptake of [ 14 C]GABA. The results show that changes in presynaptic function occur rapidly in response to a brief exposure to animal tests of anxiety. However, only the increased hippocampal release of 5-HT is likely to be causally linked to anxiety and the results show that this cannot be the sole explanation.


  • 주제어

    anxiety .   5-HT .   GABA .   hippocampus .   cortex .   release .   uptake.  

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