Distribution of angiotensin II receptor subtypes in the rabbit brain
We have determined the distribution of angiotensin II receptor subtypes in rabbit brain using in vitro autoradiography. AT 1 receptors were found in very high concentrations in the forebrain circumventricular organs - the subfornical organ, organum vasculosum of the lamina terminalis, and the median eminence as observed in other mammals. However, there was very little labeling in the area postrema. In the paraventricular nucleus, median preoptic nucleus, supraoptic nucleus there were high levels of predominantly AT 1 receptors. High densities of AT 1 receptors were also found in the nucleus of the solitary tract and the rostral and caudal ventrolateral medulla. All of these regions have putative roles in the regulation of blood pressure and fluid and electrolyte balance.In the rabbit brain there is less AT 2 receptor binding than the rat, with most AT 2 binding found in the molecular layer of the cerebellum and in the septohypothalamic nucleus. In the subthalamic nucleus, the mediodorsal and ventroposterior nuclei of the thalamus, locus coeruleus and inferior olivary nuclei, areas containing mostly AT 2 receptors in the rat, no binding was detected in the rabbit except in the locus coeruleus which contains moderate levels of AT 1 receptors.Taken in conjunction with our previous results in the rat and human brains, these results reveal that AT 1 receptors predominate in rostral forebrain, hypothalamus and autonomic control centers of the medulla oblongata in all three species. However, the distribution and density of AT 2 bearing sites in regions such as the septum, thalamus subthalamic nuclei, locus coeruleus, cerebellum and inferior olivary nuclei show marked species differences.
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