본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Regulatory peptides v.44 no.2, 1993년, pp.199 - 206  

Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells

Dudley, D.T. ; Summerfelt, R.M. ;
  • 초록  

    R3T3 cells are a fibroblast cell line found to selectively express the AT 2 subtype of angiotensin II binding sites. We have previously shown that in these cells, the AT 2 sites do not appear to be coupled to G-proteins, do not modulate any of the common second messenger pathways associated with activation of angiotensin II receptors, and do not internalize bound ligand. Here we report that expression of AT 2 sites in these cells are subject to modulation by a variety of conditions. In actively growing cells the expression of AT 2 sites is very low, while in confluent, quiescent cells, the expression of AT 2 sites is markedly increased. Addition of serum, or growth factors, to quiescent cells causes a rapid decrease in the number of cell-surface AT 2 sites. Further, incubation of cells with ligands that bind to AT 2 sites causes a marked increase in the number of these sites in a time and dose dependent manner indicating homologous up-regulation of expression. These results indicate that expression of AT 2 sites in R3T3 cells is under sensitive and rapid control and further indicate that these cells may be an excellent model for studying the physiological regulation of expression of these sites.


  • 주제어

    PD 123319 .   Receptor .   Growth factor .   Mitogen .   Fibroblast.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기