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Determination of diethylcarbamazine, an antifilarial drug, in human urine by 1H-NMR spectroscopy

Jaroszewski, Jerzy W. ; Berenstein, Dina ; Sløk, Frank A. ; Simonsen, Paul Erik ; Agger, Mette K. ;
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    Abstract 1 H-NMR spectroscopy is a convenient method for determination of diethylcarbamazine (DEC) in urine, and can be used to monitor medication with the drug. Urine samples were mixed with 10% of deuterium oxide as a spectrometer field frequency lock, which is the only sample pretreatment required. Tailored excitation with the 1 3 3 1 pulse was used for water peak suppression. The quantification of DEC was carried out with the triplet of the N-ethyl group, for which the T 1 relaxation time was 1 s. In aqueous solutions, amounts below 1 μg ml −1 of DEC could be easily detected. In urine, the detectability depended on the level of chemical noise but was better than 10 μg ml −1 . The accuracy and precision of the method were better than 15%. Analysis of urine from volunteers receiving a single therapeutic dose of DEC (6 mg kg −1 body weight orally) showed that the drug was eliminated in unchanged form during 2 days, in agreement with earlier results. The concentration of DEC in urine several hours after the intake exceeded 100 μg ml −1 making the 1 H-NMR assay rapid and easy. No significant amounts of the N-oxide of DEC could be detected.


  • 주제어

    DEC .   Quantitative 1H-NMR .   Solvent suppression .   331 Pulse ');return false;" target="_blank"> 1331 Pulse .   Urine analysis .   Drug excretion .   Drug metabolism .   Diethylcarbamazine N-oxide.  

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