본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Determination of diethylcarbamazine, an antifilarial drug, in human urine by 1H-NMR spectroscopy

Jaroszewski, Jerzy W. ; Berenstein, Dina ; Slø ; k, Frank A. ; Simonsen, Paul Erik ; Agger, Mette K. ;
  • 초록  

    Abstract 1 H-NMR spectroscopy is a convenient method for determination of diethylcarbamazine (DEC) in urine, and can be used to monitor medication with the drug. Urine samples were mixed with 10% of deuterium oxide as a spectrometer field frequency lock, which is the only sample pretreatment required. Tailored excitation with the 1 3 3 1 pulse was used for water peak suppression. The quantification of DEC was carried out with the triplet of the N-ethyl group, for which the T 1 relaxation time was 1 s. In aqueous solutions, amounts below 1 μg ml −1 of DEC could be easily detected. In urine, the detectability depended on the level of chemical noise but was better than 10 μg ml −1 . The accuracy and precision of the method were better than 15%. Analysis of urine from volunteers receiving a single therapeutic dose of DEC (6 mg kg −1 body weight orally) showed that the drug was eliminated in unchanged form during 2 days, in agreement with earlier results. The concentration of DEC in urine several hours after the intake exceeded 100 μg ml −1 making the 1 H-NMR assay rapid and easy. No significant amounts of the N-oxide of DEC could be detected.


  • 원문보기

    원문보기
    무료다운로드 유료다운로드
    • 원문이 없습니다.

    유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

  • 주제어

    DEC .   Quantitative 1H-NMR .   Solvent suppression .   331 Pulse ');return false;" target="_blank"> 1331 Pulse .   Urine analysis .   Drug excretion .   Drug metabolism .   Diethylcarbamazine N-oxide.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역