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Biochemical pharmacology v.51 no.12, 1996년, pp.1593 - 1600  

Nitric oxide (NO•), the only nitrogen monoxide redox form capable of activating soluble guanylyl cyclase

Dierks, Elizabeth A. ; Burstyn, Judith N. ;
  • 초록  

    Abstract In the present study, we determined that of the redox forms of nitrogen monoxide, NO − , NO • and NO + , only NO . significantly activates soluble guanylyl cyclase (GTP pyrophosphate-lyase cyclizing, EC 4.6.1.2). Neither of the NO − donors tested, Angeli's salt (Na 2 N 2 O 3 ) or Piloty's acid (C 6 H 5 SO 2 NHOH), caused a change in the guanylyl cyclase activity relative to the basal activity level. Interference by other reaction products was eliminated as a possible explanation for the lack of activation. To the extent that NO + could be stabilized in aqueous solution, by dissolution of the nitrosonium salt NOPF 6 in dry organic solvent prior to addition to the enzyme in buffer, NO + had no effect on the activity of soluble guanylyl cyclase. The counter-ion, PF 6 − , had a minimal effect on the enzyme activity and, therefore was, not responsible for the lack of activation by NO + . These observations suggest that NO . is the natural activator of soluble guanylyl cyclase and is reasonably identical with endothelium-derived relaxing factor, the physiological regulator of soluble guanylyl cyclase activity.


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  • 주제어

    soluble guanylyl cyclase .   nitric oxide .   nitroxyl .   nitrosonium .   endothelium-derived relaxing factor (EDRF).  

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