본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Biochemical pharmacology v.51 no.12, 1996년, pp.1719 - 1725  

Inhibition of lipid peroxidation in low-density lipoprotein by the flavonoid myrigalone B and ascorbic acid

Mathiesen, Liv ; Wang, Siri ; Halvorsen, Bente ; Malterud, Karl E. ; Sund, Reidar B. ;
  • 초록  

    Abstract Lipid peroxidation in human LDL (0.05 mg protein/mL) incubated with Cu 2+ -ions (5 μM) in vitro was dose-dependently inhibited by the flavonoid myrigalone B (MyB) and by ascorbic acid. MyB at 6 μM increased the oxidation lag time by 135 ± 24 min (approximately 5-fold compared to controls) and reduced the maximum oxidation rate by 46 ± 5%. Ascorbic acid, at 9 μM, increased the lag time by 179 ± 29 min (6-fold compared to controls) but did not affect the maximum oxidation rate. The increase in lag time induced by MyB was enhanced in the presence of ascorbic acid. Their effects were additive, except when both were present at the highest concentration tested, when a significant potentiation, giving an increase in lag time of approximately 2 hr more than the sum of separate effects, occurred. Concentration-time curves for MyB in the absence and presence of ascorbic acid showed that the vitamin protected MyB against deterioration during incubation, and indicated that the net consumption of MyB in the oxidation process was reduced. No differences were observed when ordinary ascorbic acid and Ester-C ? , a commercial vitamin C product, were compared. In conclusion, MyB and ascorbic acid seem to interact in a way that further improves the antioxidant status of the LDL particle relative to each substance separately.


  • 원문보기

    원문보기
    무료다운로드 유료다운로드
    • 무료 원문 정보가 존재하지 않습니다.

    유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

  • 주제어

    myrigalone B .   lipid peroxidation .   ascorbic acid .   oxidized LDL .   flavonoids.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역