Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO Cells
Abstract The regulation of neurotensin-induced phosphoinositide turnover was studied in transfected CHO cells expressing the rat neurotensin receptor. Stimulation of these cells with neurotensin resulted in an important, but transient, increase in inositol phosphate cell content. Preincubation of the cells with neurotensin dramatically decreased their response to further stimulation. This diminution, which was time-dependent and not related to the availability of phospholipase C substrate, is though to reflect a progressive homologous desensitization of the recombinant neurotensin receptor.
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