본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Biopolymers v.33 no.3, 1993년, pp.363 - 375  

Structure of the left-handed antiparallel amylose double helix: theoretical studies

Schulz, Wolfgang (Max Delbruck Centrum fur Molekulare MedizinBerlinGer ); Sklenar, Heinz ( ); Hinrichs, Winfried ( ); Saenger, Wolfram ( );
  • 초록

    The atomic coordinates from the crystal structure of a hexasaccharide complex accommodating a zigzag polyiodide [W. Hinrichs, G. Buttner, M. Steifa, Ch. Betzel, V. Zabel, B. Pfannemuller, and W. Saenger (1987) Science Vol. 238, pp. 205-208; W. Hinrichs and W. Saenger (1990) Journal of the American Chemical Society, Vol. 112, pp. 2789-2796] served to construct an antiparallel-stranded amylose double helix with a 5 angstrom wide central cavity. Using our methodology for the energetic optimization of polymer structures in the internal/helical variable space [H. Sklenar, R. Lavery, and B. Pullman (1986) Journal of Biomolecular Structure Dynamics, Vol. 3, pp. 967-987, 989-1014; 1015-1031], we have calculated a theoretical counterpart of this idealized double helix by constraining the helical twist and rise to their experimental values (-45° and 2.33 angstrom, respectively). Applying the same constraints to the parallel-stranded duplex, this also leads to a low-energy structure with wide central cavity. It is considered as an alternative model to accommodate iodine as observed in the starch-iodine complex. Release of the helical constraints leads to left-handed antiparallel- and parallel-stranded double helices, respectively, with narrow central cavities. Both structures have very similar helix parameters and correspond, in their main characteristics, to the experimentally derived parallel-stranded structure of amylose in starch (6 residues per turn and a pitch height of about 21 angstrom). The intramolecular energy calculated for the optimized antiparallel-stranded amylose double helix is comparable to that of the parallel-stranded structure. This result raises the question why parallel-stranded amylose seems to be favored in nature.(Author abstract)


 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기