Determinants of oxygenation during high frequency oscillation
Abstract Two studies are reported in which the aim was to assesses whether oxygenation on transfer to or during high frequency oscillation (HFO) was influenced by the mean airway pressure (MAP) level. Sixteen infants, median gestational age 28 weeks, were recruited into the first study and 14 with a median gestational age of 29 weeks into the second. In the initial study, blood gases were measured immediately before and 30 min after transfer to HFO and comparison made of those infants in whom oxygenation did or did not improve. In the second study the infants were studied at two MAP levels, 2 and 5 cmH 2 O, above that used during conventional ventilation (baseline MAP) and at two frequencies (10 and 15 Hz), arterial blood gases were measured after 20 min on each setting. In the initial study, on transfer to HFO, oxygenation improved by a median of 21 mmHg in eight infants, but was either unchanged or deteriorated ( n = 7) in the other eight infants, the median impairment in oxygenation was by 17 mm Hg. The infants in whom oxygenation improved had required a significantly higher MAP during conventional ventilation than the rest of the study group. In the second study, increasing the MAP from 2 to 5 cmH 2 O above baseline resulted in a significant increase in oxygenation, which was significantly greater at 10 rather than 15 Hz. Infants whose MAP remained below 13 cmH 2 O had impaired oxygenation during HFO compared to that experienced during conventional ventilation. The results of these two studies demonstrate that the MAP level during HFO is an important determinant of oxygenation.
원문보기 무료다운로드 유료다운로드
- NDSL :
유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.
NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.