본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Clinical experiences with ofloxacin sequential therapy in chronic ear infections

Heppt, W. ; Lutz, H. ;
  • 초록  

    Summary Quinolones are the drugs of first choice in therapy of chronic ear infections with multiresistant bacteria, especially because of their efficacy against various Pseudomonas species and their lack of ototoxicity. According to clinical experience, best results can be obtained after application of the sequential treatment schedule. To verify this, 61 patients with acute exacerbations of chronic ear infections were treated sequentially with ofloxacin. After a single dose of 400 mg ofloxacin intravenously, the treatment was continued orally with 400 mg once a day over 7 days. Microbiological and serological examination was performed just prior to and 1 week after treatment. Predominant bacteria isolated from the patients' ears were Pseudomonas aeruginosa, Staphylococcus aureus, Proteus spp. and Enterobacteriaceae spp. Following treatment, infections were cured in 23% of cases and 59% showed improvement. Eigtheen percent of the cases were persistent, mainly due to epitympanic chronic otitis media, which was an indication for surgical intervention. In general, sequential therapy with ofloxacin revealed encouraging clinical results based on improved patient compliance with the treatment schedule recommended.


  • 원문보기

    원문보기
    무료다운로드 유료다운로드
    • NDSL :

    유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

  • 주제어

    Chronic otitis .   Pseudomonas infection .   Quinolone .   Ofloxacin.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역