Effects of chemotherapy and radiotherapy on spermatogenesis.
Radiation and chemotherapy reduce sperm count and cause infertility in males. In the mouse, rat, and human, the differentiating spermatogonia are the most sensitive to killing by cytotoxic agents, resulting in short-term azoospermia. Stem spermatogonia are also killed by some agents. In the mouse, sperm production gradually recovers from surviving stem cells without a lag period. In the rat, however, surviving stem cells may remain as A spermatogonia for long times without initiating differentiation. In humans, there may be a long period of azoospermia; the time at which recovery or sperm production is initiated appears to be related to the degree of stem cell killing. Knowledge of the mechanisms regulating spermatogonial proliferation and differentiation could lead to ways to minimize the duration of azoospermia following treatment.
원문보기 무료다운로드 유료다운로드
- 무료 원문 정보가 존재하지 않습니다.
- 유료 원문 정보가 존재하지 않습니다.
NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.