Escherichia coli K-12 ferrous iron uptake mutants are impaired in their ability to colonize the mouse intestine
The streptomycin-treated mouse colonization model was used to investigate the role of the Fe 2+ uptake system (Feo) of Escherichia coli K12 in the colonization of the mouse intestine. Mutants impaired in the uptake of Fe 2+ ions were shown to be deficient also in their colonization ability. Both enterochelin-producing and enterochelin-nonproducing Escherichia coli feo mutants were unable to colonize the mouse intestine. These results demonstrated that Fe(II) is an essential source of iron for E. coli grown in the intestine.
- DOI : http://dx.doi.org/10.1016/0378-1097(93)90496-O
- Oxford University Press : 저널 > http://femsle.oxfordjournals.org/content/108/1/111.abstract
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