Resolved 2-arylcyclohexylamines: Effects on reserpine akinesia and central nervous system monoamine synthesis
A series of cis- and trans-2-arylcyclohexylamines were synthesized and resolved. The absolute configuration was determined by single-crystal X-ray analysis. Some of the compounds, and especially racemic 2-(3-hydroxyphenyl)-N,N-dipropylcyclohexylamine showed a marked locomotor stimulation in reserpinized rats. However, these compounds displayed only minor effects on dopamine and 5-hydroxytryptamine synthesis rates, indicating a non-dopaminergic and/or serotonergic mechanism for this stimulation.
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