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Spontaneous Synaptic Transmission in Dissociated Meynert Neurons with the Attached Synaptic Boutons

Harata, N. ; Ueno, S. ; Munakata, M. ; Akaike, N. ;
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    1. Neurons acutely dissociated from the nucleus basalis of Meynert of adult rats showed spontaneous currents with rapid onset and slow decay under the whole-cell patch-clamp recording.2. The current had the reversal potential close to the theoretical Cl - equilibrium potential (E Cl ) and was suppressed by 2 x 10 -6 M bicuculline and 3 x 10 -6 M strychnine.3. The spontaneous current was suppressed reversibly in the Ca 2+ -free solution containing either EGTA or BAPTA (5mM). The enhancement of the frequency and amplitude of the current was observed with elevated extracellular K + concentration, which was also suppressed in the presence of the Ca 2+ -free solution.4. Nicardipine, a blocker of voltage-dependent Ca 2+ channels, had an inhibitory effect as well.5. A selective GABA B agonist, baclofen, blocked the spontaneous current, whereas a selective antagonist, phaclofen, potently enhanced the current.6. It is concluded that the observed spontaneous current was a spontaneous inhibitory postsynaptic current (IPSC) due to the release of GABA from the attached synaptic boutons. The release was suppressed by a GABA B receptor activation, indicating that the GABA B receptor regulates the release of GABA from nerve terminals and acts as a negative autoreceptor.


  • 주제어

    baclofen .   calcium .   dissociated Meynert neuron .   GABA .   phaclofen .   rat .   synaptic button.  

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