본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Functional studies on monoaminergic transmitter release in parkinsonism

Wesemann, W. ; Grote, C. ; Clement, H.-W. ; Block, F. ; Sontag, K.-H. ;
  • 초록  

    1. In vivo pulse voltammetry and apomorphine induced circling behaviour were used to study the effect of antiparkinsonian drugs and neurotoxins on striatal, extraneuronal dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations which are a measure of dopamine (DA) release / DA metabolism and serotonin (5-HT) release, respectively.2. The DA precursor dihydroxyphenylalanine (DOPA, i.p.) increased extraneuronal DOPAC and reduced 5-HIAA levels whereas the opposite effect was induced by the 5-HT precursor 5-hydroxytrytophan (5-HTP, i.p.). Tryptophan, i.p., decreased the extraneuronal DOPAC levels without significant effect on 5-HT release.3. The monoamine oxidase (MAO) inhibitors pargyline, i.p., and deprenyl, i.p., as well as the DA agonist apomorphine, i.p., decreased the catechol signal. The DA antagonist haloperidol, i.p., increased extraneuronal DOPAC.4. In longterm studies unilateral application of the neurotoxins 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP), and 1-methyl-4-phenylpyridiniumcation (MPP + ) into the substantia nigra pars compacta abolished the DOPAC signal in the striatum at the lesioned side. This effect can be partially or fully restored by DOPA depending on the time elapsed after neurotoxin administration.5. In accordance with the voltammetric recorded unilateral lesion of the dopaminergic system the apomorphine stimulated circling behaviour was significantly enhanced in MPTP and MPP + treated rats as compared with controls.6. The results obtained indicate that antiparkinsonian drugs and neurotoxins besides their effect on total catecholamine and 5-HT concentrations change specifically the extraneuronal levels of the transmitter (metabolites). Moreover the results suggest that neurotoxin-treated rats can be used as a model to study Parkinson-like effects with regard to the pathogenesis and treatment of this disease.


  • 원문보기

    원문보기
    무료다운로드 유료다운로드
    • 무료 원문 정보가 존재하지 않습니다.

    유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

    NDSL에서는 해당 원문을 복사서비스하고 있습니다. 아래의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

  • 주제어

    circling behaviour .   dihydroxyphenylacetic acid .   dopamine .   5-hydroxyindolacetic acid .   6-hydroxydopamine .   1-methyl-4-phenylpyridiniumcation .   1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine .   neurotoxins .   parkinsonism .   rat .   serotonin .   striatum.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역