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A Case of Coagulation Factor V Deficiency Complicated with Intracranial Hemorrhage

Yoon, Suk-Gu    (Institute for Clinical Molecular Biology Research and Department of Internal Medicine, College of Medicine Soonchunhyang University, Seoul, Korea   ); Cho, Sung-Tae    (Institute for Clinical Molecular Biology Research and Department of Internal Medicine, College of Medicine Soonchunhyang University, Seoul, Korea   ); Park, Sung-Kyu    (Institute for Clinical Molecular Biology Research and Department of Internal Medicine, College of Medicine Soonchunhyang University, Seoul, Korea   ); Won, Jong-Ho    (Institute for Clinical Molecular Biology Research and Department of Internal Medicine, College of Medicine Soonchunhyang University, Seoul, Korea   ); Baick, Seung-Ho    (Institute for Clinical Molecular Biology Research and Department of Internal Medicine, College of Medicine Soonchunhyang University, Seoul, Korea   ); Hong, Dae-Sik    (Institute for Clinical Molecular Biology Research and Department of Internal Medicine, College of Medicine Soonchunhyang University, Seoul, Korea   ); Park, Hee-Sook    (Institute for Clinical Molecular Biology Research and Department of Internal Medicine, College of Medicine Soonc  );
  • 초록

    Factor V deficiency is a relatively uncommon disorder, inherited as an autosomal recessive trait that manifests clinically only in individuals who inherit the defective gene from both parents. The hemorrhage of nasal and oral cavity and ecchymosis are common but intracranial hemorrhage is very rare. We experienced a 53 year old male patient with intracranial hemorrhage due to factor V deficiency. The laboratory tests showed prolongation of APTT and PT, normal bleeding time and normal thrombin time. The levels of the coagulation profiles on the patient revealed a significant decrease of factor V, below 1% of normal range(60–140%). Other coagulation factors were normal. He was treated with fresh frozen plasma and completely recovered 3 weeks after treatment.


  • 주제어

    Factor V deficiency .   Intracranial hemorrhage.  

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