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Journal of Korean medical science : JKMS v.19 no.6 = no.100, 2004년, pp.812 - 814  
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Alpha-Adducin Gly460Trp Polymorphism and Essential Hypertension in Korea

Shin, Min-Ho    (Department of Preventive Medicine, College of Medicine, Seonam University, Gwangju, Korea.   ); Chung, Eun-Kyung    (Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.   ); Kim, Hee-Nam    (Genomic Research Center of Hematopoietic Diseases, Chonnam National University Hospital, Gwangju, Korea.   ); Park, Kyeong-Soo    (Department of Preventive Medicine, College of Medicine, Seonam University, Gwangju, Korea.   ); Nam, Hae-Sung    (Department of Preventive Medicine, College of Medicine, Seonam University, Gwangju, Korea.   ); Kweon, Sun-Seog    (Department of Preventive Medicine, College of Medicine, Seonam University, Gwangju, Korea.   ); Choi, Jin Su    (Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.  );
  • 초록

    Previous studies have suggested that the Gly460Trp polymorphism of the alpha-adducin gene ( ADD-1 ) is associated with salt sensitivity and primary hypertension. The results of linkage or association studies of ADD-1 of different populations are controversial. This study investigated the relationship between the Gly460Trp polymorphism of ADD-1 and essential hypertension in a Korean population. The subjects (n=903) were participants in a population-based study in Jangseong County, Korea. The Gly460Trp polymorphism of ADD-1 was determined using a polymerase chain reaction method. The frequency of the 460Trp allele was 59.4% in normotensives and 61.1% in hypertensives ( p = 0.523). The frequencies of the genotypes did not differ significantly between the hypertensive and normotensive groups (16.3% Gly/Gly, 45.8% Gly/Trp, and 38.0% Trp/Trp in normotensives; 16.2% Gly/Gly, 45.8% Gly/Trp, and 38.0% Trp/Trp in hypertensives; p = 0.928). After adjusting for other risk factors, Gly/Trp and Trp/Trp were not associated with hypertension (OR 1.00, 95% CI 0.65-1.53, Gly/Trp vs. Gly/Gly; OR 1.22, 95% CI 0.79-1.90, Trp/Trp vs. Gly/Gly). These findings suggest that the Gly460Trp polymorphism of ADD-1 is not associated with hypertension.


  • 주제어

    Hypertension .   Adducin .   Polymorphism, Single Nucleotide.  

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