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A Case of Severe Protein-losing Enteropathy as a Late Complication of Pelvic Irradiation

Sohn, Wee Sik    (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea   ); Kim, Duck Ryung    (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea   ); Lee, Jong Sin    (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea   ); Cheon, Gi Jeong    (Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea   ); Lee, Byung-Hee    (Department of Radiology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea   ); Lee, Seung-Sook    (Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea   ); Jeong, Sook-Hyang    (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Science, Seoul, Korea  );
  • 초록

    Protein-losing enteropathy is the manifestation of a diverse set of disorders, and it is characterized by the excessive loss of plasma proteins into the affected portions of the gastrointestinal tract, and this results in hypoalbuminemia. We report here on a case of severe protein-losing enteropathy with the typical clinical features of hypoalbuminemia, dependent edema and increased alpha 1-antitrypsin (α1-AT) clearance, as measured by using 24hr stool testing. The associated disorder with the protein-losing enteropathy of our case was radiation enterocolitis and lymphatic obstruction that was due to radiation treatment and lymph node dissection in the remote past for the treatment of uterine cervical carcinoma. Our case suggests that chronic radiation enterocolitis can result in irreversible injury to the intestinal mucosa and a protein-losing enteropathy, which can bring about a very poor quality of life and even the loss of life.


  • 주제어

    Protein-losing enteropathy .   Radiation .   Enterocolitis.  

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