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Chronic Hypoxia Alters Vasoconstrictive Responses of Femoral Artery in the Fetal Sheep

Kim, Yoon Ha    (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea.   ); Veille, Jean-Claude    (Albany Medical College, Albany, New York 12208, U.S.A.   ); Cho, Moon Kyoung    (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea.   ); Kang, Myoung Seon    (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea.   ); Kim, Cheol Hong    (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea.   ); Song, Tae-Bok    (Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea.   ); Figueroa, Jorge P.    (Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, U.S.A.  );
  • 초록

    The purpose of this study was to determine if mild hypoxia alters the responsiveness to vasoactive agents in the renal and the femoral arteries in the fetal sheep. Ten pregnant sheep were operated under halothane anesthesia at 116 to 124 days' gestation. A maternal tracheal catheter was placed for infusing compressed air (control group, n=5) or nitrogen (hypoxia group, n=5) starting on post operative day 6 and maintained for 5 days. Femoral and renal arteries were harvested from the fetus to study the constriction response to phenylephrine (PE 10 -9 to 10 -5 mol/L). To determine the involvement of nitric oxide as a modulator of vessel constriction, N-nitro-L-arginine methyl ester (L-NAME) was used at a concentration of 10 -4 mol/L in parallel chambers. In the hypoxia group, maternal Pao 2 significantly decreased from a baseline of 110.4±1.4 to 80.5±1.6 (mmHg, p 2 significantly decreased from a baseline of 20.9±0.3 to 15.5±0.1 (mmHg, p 50 in the absence (6.0±1.1 vs. 27.0±4.1) of L-NAME of femoral arteries. However, there were no significant differences in PE maximal response and EC 50 in the absence and presence of L-NAME of renal arteries. We concluded that mild chronic hypoxia seems to increase the fetal femoral artery response to PE, but not in the fetal renal artery. This observation is consistent with a redistribution of cardiac output away from the carcass.


  • 주제어

    Anoxia .   Femoral artery .   Blood Vessels .   Phenylephrine.  

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