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Effects of Methylprednisolone on the Neural Conduction of the Motor Evoked Potentials in Spinal Cord Injured Rats

Lee, Bae Hwan    (Department of Neurosurgery, Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.   ); Lee, Kyung Hee    (Department of Neurosurgery, Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.   ); Yoon, Do Heum    (Department of Neurosurgery, Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.   ); Kim, Un Jeng    (Department of Neurosurgery, Medical Research Center, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.   ); Hwang, Yong Soon    (Department of Neurosurgery, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.   ); Park, Sang Keun    (Department of Neurosurgery, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.   ); Choi, Joong Uhn    (Department of Neurosurgery, Medical Research Center, Brain Research Institute, B  ); Park, Yong Gou  
  • 초록

    Methylprednisolone (MP), a glucocorticoid steroid, has an anti-inflammatory action and seems to inhibit the formation of oxygen free radicals produced during lipid peroxidation in a spinal cord injury (SCI). However, the effects of MP on the functional recovery after a SCI is controversial. The present study was conducted to determine the effects of MP on the recovery of neural conduction following a SCI. A SCI was produced using the NYU spinal cord impactor. A behavioral test was conducted to measure neurological disorders, and motor evoked potentials (MEPs) were recorded. According to the behavioral test, using BBB locomotor scaling, MP-treated animals showed improved functional recoveries when compared to salinetreated animals. MEP latencies in the MP-treated group were shortened when compared to those in the control group. Peak amplitudes of MEPs were larger in the MP-treated group than those in the control group. The thresholds of MEPs tended to be lower in the MP-treated group than those in the control group. These results suggest that MP may improve functional recovery after a SCI.


  • 주제어

    Spinal Cord Injuries .   Methylprednisolone .   Behavior .   Evoked Potentials .   Recovery of Function.  

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