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A Case of Melioidosis Presenting as Migrating Pulmonary Infiltration: The First Case in Korea

Lee, Sei Won    (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.   ); Yi, Jongyoun    (Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.   ); Joo, Sae-Ik    (Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.   ); Kang, Young Ae    (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.   ); Yoon, Young Soon    (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.   ); Yim, Jae-Joon    (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.   ); Yoo, Chul-Gyu    (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.   ); Han, Sung Koo    (Division of Pulmonary and Critical Care Medicine, Department of Internal M  ); Shim, Young-Soo   Kim, Eui-Chong   Kim, Young Whan  
  • 초록

    Melioidosis is an infection of the Gram-negative bacterium Burkholderia pseudomallei . While it is known as an important cause of sepsis or chronic abscess-forming disease in Southeast Asia and northern Australia, no case has yet been reported in Korea. A 50-yr-old man visited our hospital for intermittent fever associated with dry cough and sputum. Roentgenographic examination showed migrating pulmonary infiltration. Symptoms and chest radiograph and computed tomography (CT) image findings did not improve despite use of fluoroquinolone antibiotics. Gram-negative bacteria were isolated on bronchoscopic washing culture and were identified as B. pseudomallei on DNA sequencing of 16S ribosomal RNA with 100% homology. Treatment for melioidosis was commenced with high dose ceftazidime, and the patient's fever, cough, and sputum were improved and the lesion on chest radiograph and CT almost disappeared.


  • 주제어

    Melioidosis .   Burkholderia pseudomallei .   Korea .   Communicable Diseases .   Lung Diseases.  

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