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DNA Hypermethylation of Tumor-Related Genes in Gastric Carcinoma

Hong, Su Hyung    (Department of Dental Microbiology, Kyungpook National University School of Dentistry, Daegu, Korea.   ); Kim, Ho Gak    (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.   ); Chung, Woon Bok    (Department of Dental Microbiology, Kyungpook National University School of Dentistry, Daegu, Korea.   ); Kim, Eun Young    (Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.   ); Lee, Jong Young    (Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea.   ); Yoon, Sang Mo    (Department of Therapeutic Radiology and Oncology, Yeungnam University College of Medicine, Daegu, Korea.   ); Kwon, Joong Goo    (Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea.   ); Sohn, Yoon Kyung    (Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.   ); Kwak, Eun Kyung    (Department of Pathology, Kyungpook National University School of Dentistry, Daegu, Korea.   ); Kim, Jung Wan    (Department of Dental Microbiology, Kyungpook National University School of Dentistry, Daegu, Korea.  );
  • 초록

    The hypermethylation of the CpG islands is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed the methylation status of genes for cell repair such as hMLH1 , MGMT , and GSTP1 , and a gastric cancer-specifically methylated DNA fragment, MINT 25 in gastric cancer cases and control groups. The study population consisted of 100 gastric cancer patients (50 distal and 50 proximal carcinomas), and 238 healthy controls. All genes showed more frequent hypermethylation in the cases than in the control group ( p hMLH1 ( p = 0.008), MGMT ( p = 0.0001), and GSTP1 ( p = 0.0003) in females. This study also demonstrates that hypermethylation was strongly associated with non-drinkers ( MGMT , p = 0.046 and MINT 25 , p = 0.049) and non-smokers ( hMLH1 , p = 0.044; MGMT , p = 0.0003; MINT 25 , p = 0.029). Moreover, the frequency of MINT 25 hypermethylation increased with age ( p = 0.037), and MGMT methylation was frequently detected in distal gastric cancer than in proximal type ( p = 0.038). Our study suggested that promoter hypermethylation of the genes involved in cell repair system and MINT 25 is associated strongly with some subgroups of primary gastric carcinoma.


  • 주제어

    Stomach Neoplasms .   DNA Methylation .   MLH1 Protein, mammalian .   O(6)-Methylguanine-DNA Methyltransferase .   Glutathione S-transferase pi .   MINT 25.  

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