DNA Hypermethylation of Tumor-Related Genes in Gastric Carcinoma
The hypermethylation of the CpG islands is a common mechanism for the inactivation of tumor-related genes. In the present study, we analyzed the methylation status of genes for cell repair such as hMLH1 , MGMT , and GSTP1 , and a gastric cancer-specifically methylated DNA fragment, MINT 25 in gastric cancer cases and control groups. The study population consisted of 100 gastric cancer patients (50 distal and 50 proximal carcinomas), and 238 healthy controls. All genes showed more frequent hypermethylation in the cases than in the control group ( p hMLH1 ( p = 0.008), MGMT ( p = 0.0001), and GSTP1 ( p = 0.0003) in females. This study also demonstrates that hypermethylation was strongly associated with non-drinkers ( MGMT , p = 0.046 and MINT 25 , p = 0.049) and non-smokers ( hMLH1 , p = 0.044; MGMT , p = 0.0003; MINT 25 , p = 0.029). Moreover, the frequency of MINT 25 hypermethylation increased with age ( p = 0.037), and MGMT methylation was frequently detected in distal gastric cancer than in proximal type ( p = 0.038). Our study suggested that promoter hypermethylation of the genes involved in cell repair system and MINT 25 is associated strongly with some subgroups of primary gastric carcinoma.
- DOI : http://dx.doi.org/10.3346/jkms.2005.20.2.236
- 대한의학회 : 저널
- PubMed Central : 저널 > https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808599
- Synapse : 저널
- 원문이 없습니다.
원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.
NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.
- 이 논문과 함께 출판된 논문 + 더보기