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Short-term Effects of 308-nm Xenon-chloride Excimer Laser and Narrow-band Ultraviolet B in the Treatment of Vitiligo: A Comparative Study

Hong, Seok-Beom    (Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.   ); Park, Hyun-Ho    (Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.   ); Lee, Mu-Hyoung    (Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.  );
  • 초록

    We compared the clinical efficacy of a short-term intervention of 308-nm excimer laser with that of narrow-band UVB (NBUVB) phototherapy for vitiligo patients to see the early response. Twenty-three symmetrically patterned patches of vitiligo on 8 patients were selected. Vitiligo patches on one side of the body were treated 2 times per week for a maximum of 20 treatments with the excimer laser, and NBUVB phototherapy was used on patches on the other side. Improvement (repigmentation) was assessed on a visual scale via serial photographs taken every five treatments and scored as follows: 0, ≤1% improvement; 1, ≤25% improvement; 2, 26-50% improvement; 3, 51-75% improvement; and 4, ≥75% improvement. At five treatments, the excimer laser-treated patches had an average score of 0.26, compared with 0.04 for patches treated with NBUVB phototherapy. A slightly higher repigmentation ( p >0.05) in the excimer treated area was thus observed. At 10, 15, or 20 treatments, the differences between the average scores were significant: 0.83, 1.17, and 1.39 for the excimer-treated patches, and 0.17, 0.30, and 0.74 for the NBUVB phototherapy-treated areas ( p


  • 주제어

    Vitiligo .   308-nm Excimer Laser .   Laser Therapy, Low-Level .   Narrow Band UVB .   Phototherapy .   Ultraviolet Therapy.  

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