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Neuroprotective Effect of Ginseng Total Saponins in Experimental Traumatic Brain Injury

Ji, Yong Cheol    (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.   ); Kim, Young Baeg    (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.   ); Park, Seung Won    (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.   ); Hwang, Sung Nam    (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.   ); Min, Byung Kook    (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.   ); Hong, Hyun Jong    (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.   ); Kwon, Jeong Taik    (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.   ); Suk, Jong Sik    (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.  );
  • 초록

    In the present study, we investigated whether ginseng total saponins (GTSs) protect hippocampal neurons after experimental traumatic brain injury (TBI) in rats. A moderate-grade TBI was made with the aid of a controlled cortical impact (CCI) device set at a velocity of 3.0 m/sec, a deformation of 3.0 mm, and a compression time of 0.2 sec at the right parietal area for adult male Sprague-Dawley rats. Sham-operated rats that underwent craniectomy without impact served as controls. GTSs (100 and 200 mg/kg) or saline was injected intraperitoneally into the rats immediately post-injury. Twenty-four hours after the injury, the rats underwent neurological evaluation. Contusion volume and the number of hippocampal neurons were calculated with apoptosis evaluated by TUNEL staining. 24 hr post-injury, saline-injected rats showed a significant loss of neuronal cells in the CA2 region of the right hippocampus (53.4%, p p


  • 주제어

    Brain Injuries .   Panax .   Saponins .   Neuroprotective Agents .   Hippocampus.  

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