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Correlation Between Levels of N-terminal Pro-B-Type Natriuretic Peptide and Degrees of Heart Failure

Song, Bong Geun    (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea.   ); Jeon, Eun Seok    (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea.   ); Kim, Yong Hoon    (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea.   ); Kang, Min Kyung    (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea.   ); Doh, Joon Hyung    (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea.   ); Kim, Phil Ho    (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea.   ); Ahn, Seok Jin    (Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Ce  ); Oh, Hye Lim   Kim, Hyun-Joong   Sung, Ji Dong   Lee, Sang Chol   Gwon, Hyeon Cheol   Kim, June Soo   Kim, Duk-Kyung   Lee, Sang Hoon   Hong, Kyung Pyo   Park, Jeong Euy   Lee, Soo Youn   Lee, Jong Koo  
  • 초록

    Background The N-terminal fragment of pro Brain Natriuretic Peptide (NT-pro BNP) is a neuro-hormone synthesized in the cardiac ventricles in response to increased wall tension. The purpose of this study was to assess the correlation between the NT-pro BNP levels and the New York Heart Association function class (NYHA Fc) of dyspnea and echocardiographic findings for the patients who visited our cardiology departments. Methods From October, 2002 to April, 2003, serum NT-pro BNP levels were measured in 348 patients who visited the Samsung Medical Center and the Jong Koo Lee Heart Clinic. Results The NT-pro BNP levels were increased with the progression of NYHA Fc of dyspnea ( p p p p p p p p = 0.017), the left ventricular internal dimension as well as the decrease in the ejection fraction ( p Conclusion The NT-pro BNP levels were positively correlated with the NYHA Fc of dyspnea and the systolic dysfunction for the patients who visited our cardiology departments. A 300 pg/mL value for the NT-pro BNP cut-off point appears to be a sensitive level to differentiate dyspnea originating from an ailing heart or not for the patients who visited our cardiology departments.


  • 주제어

    Natriuretic peptides .   Heart failure .   Myocardial ischemia.  

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