본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Zinc-containing tricalcium phosphate and related materials for promoting bone formation

  • 초록

    Calcium phosphate is a suitable carrier of zinc, an essential element that has stimulatory effects on bone formation in vitro and in vivo as well as an inhibitory effect on osteoclastic bone resorption in vitro. The highest zinc content is attained in β-tricalcium phosphate, where the zinc content reaches 6wt%. Both rat and human bone marrow cells (BMCs) cultured on zinc-containing β-tricalcium phosphate and hydroxyapatite composite ceramics differentiated more than BMCs cultured on zinc-free composite ceramics in the presence of β-glycerophosphate and dexamethasone. The acceptable dose of zinc was higher for human BMCs than for rat BMCs. The solubility of ZnTCP, which contains a nontoxic level of zinc, decreased to 52-92% that of pure TCP in the pH range of 5.0-7.4. However, the resorbed volume of ZnTCP was much lower than that expected from the in vitro solubility of ZnTCP, becoming as low as 26-20% that of TCP, which indicates that the reduction in the resorbability of ZnTCP would be attributable principally to its lowered cellular activation property relative to that associated with pure TCP. Probably due to the lowered cellular activation property associated with ZnTCP, bone loss at the bone-implant interface was significantly arrested in the long-term implantation of ZnTCP/HAP. The intramuscular injection of ZnTCP powder is effective in increasing bone mineral density in the vicinity of the injected site in osteopenic animals. All these findings suggest that zinc-containing calcium phosphate is a biomaterial that promotes bone formation.


 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기