본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Overlapping Gene Mutations of Hepatitis B Virus in a Chronic Hepatitis B Patient with Hepatitis B Surface Antigen Loss during Lamivudine Therapy

Lee, Sun-Young    (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.   ); Choi, Moon Seok    (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.   ); Lee, Dongho    (Digestive Disease Research Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.   ); Lee, Joon Hyoek    (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.   ); Koh, Kwang Cheol    (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.   ); Paik, Seung Woon    (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.   ); Yoo, Byung Chul    (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.  );
  • 초록

    Disappearance of hepatitis B surface antigens (HBsAg) in chronic hepatitis B usually indicates clearance of hepatitis B virus (HBV) infection. However, false HBsAg negativity with mutations in pre-S2 and 'a' determinant has been reported. It is also known that YMDD mutations decrease the production of HBV and escape detection of serum HBsAg. Here, we report overlapping gene mutations in a patient with HBsAg loss during the lamivudine therapy. After 36 months of lamivudine therapy in a 44-yr-old Korean chronic hepatitis B patient, serum HBsAg turned negative while HBV DNA remained positive by a DNA probe method. Nucleotide sequence of serum HBV DNA was compared with the HBV genotype C subtype adr registered in NCBI AF 286594. Deletion of nucleotides 23 to 55 (amino acids 12 to 22) was identified in the pre-S2 region. Sequencing of the 'a' determinant revealed amino acid substitutions as I126S, T131N, M133T, and S136Y. Methionine of rtM204 in the P gene was substituted for isoleucine indicating YIDD mutation (rtM204I). We identified a HBV mutant composed of pre-S2 deletions and 'a' determinant substitutions with YMDD mutation. Our result suggests that false HBsAg negativity can be induced by combination of overlapping gene mutations during the lamivudine therapy.


  • 주제어

    Hepatitis B, Chronic .   Hepatitis B Surface Antigens .   Hepatitis B virus .   Lamivudine .   Mutation.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

유료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기