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Clinical Effectiveness of Urinary Human Chorionic Gonadotropin Related Protein (hCGRP) Quantification for Diagnosis of Ectopic Pregnancy

Lee, Jae-Kwan    (Department of Obstetrics and Gynecology, Korea University School of Medicine, Seoul, Korea.   ); Oh, Min-Jeong    (Department of Obstetrics and Gynecology, Korea University School of Medicine, Seoul, Korea.   ); Shin, Joong-Sik    (Department of Obstetrics and Gynecology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.   ); Lee, Kyung-Joo    (Department of Obstetrics and Gynecology, College of Medicine Pochon CHA University, Seoul, Korea.   ); Nam, Jung-Hyun    (Department of Obstetrics and Gynecology, Humasis Research Center, Gunpo, Korea.   ); Cha, Jung-Hak    (Department of Obstetrics and Gynecology, Humasis Research Center, Gunpo, Korea.   ); Chang, Jin-Dong    (Department of Obstetrics and Gynecology, Humasis Research Center, Gunpo, Korea.   ); Cho, Dong-Hee    (Department of Obstetrics and Gynecology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.   ); Kang, In-Soo    (Department of Obstetrics and Gynecology, Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.   ); Lee, Paul I    (Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, PA, USA  );
  • 초록

    We detected pregnancy related new molecule, human chorionic gonadotropin related protein (hCGRP) in the urine of a pregnant women by using a monoclonal antibody against the human chorionic gonadotropin (hCG). This study examined the effectiveness of urinary hCGRP quantification in diagnosing ectopic pregnancy. This study included 40 normal pregnant women and 25 patients with ectopic pregnancy. Patients' serum and urinary intact whole hCG (i-hCG) and hCGRP concentrations were measured using sandwich ELISA and the ratio of hCGRP to i-hCG was calculated. Statistical analysis was performed using statistical package for social sciences (SPSS) 10.0. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the cut-off value to discriminate ectopic pregnancies from normal intrauterine pregnancies. Urinary hCGRP and hCGRP/i-hCG ratio in ectopic pregnancy group (14±6.6 ng/mL, 4.6±1.9%, respectively) were significantly lower than those of normal pregnancy group (149±10.2 ng/mL, 29.7±1.9%, respectively; p


  • 주제어

    Pregnancy, Ectopic .   Early Diagnosis .   Chorionic Gonadotropin .   Human Chorionic Gonadotropin Related Protein.  

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