본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in Koreans

Kim, Joong-Seok    (Department of Neurology, The Catholic University of Korea, Seoul, Korea.   ); Kim, Yeong-In    (Department of Neurology, The Catholic University of Korea, Seoul, Korea.   ); Song, Christopher    (Division of Biology and Medicine, Brown University, RI, U.S.A.   ); Yoon, Injin    (Department of Neurology, The Catholic University of Korea, Seoul, Korea.   ); Park, Jeong-Wook    (Department of Neurology, The Catholic University of Korea, Seoul, Korea.   ); Choi, Young-Bin    (Department of Neurology, The Catholic University of Korea, Seoul, Korea.   ); Kim, Hee-Tae    (Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea.   ); Lee, Kwang-Soo    (Department of Neurology, The Catholic University of Korea, Seoul, Korea.  );
  • 초록

    1α,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), which is the biologically active form of vitamin D, has anti-inflammatory effects and can prevent experimental Parkinson's disease (PD). 1,25(OH) 2 D 3 exerts most of its actions only after it binds to its specific nuclear receptors. Eighty-five Korean patients with PD and 231 unrelated healthy individuals were evaluated to determine if vitamin D receptor gene (VDRG) Bsm I polymorphisms were markers for the susceptibility to PD in Korean patients. Each polymorphism was detected using polymerase chain reaction (PCR)-based restriction analysis. In addition, the relationship between the Bsm I polymorphisms and the clinical manifestations of PD was evaluated. Overexpression of the b allele (91.2 vs. 85.7%; p = 0.069) and homozygote bb (84.7 vs. 72.7%; p = 0.043) was found in the PD patients compared with the controls. These results show for the first time an association between PD and a VDRG polymorphism, which might be involved in the pathogenesis of PD, or in the linkage disequilibrium of the VDRG to another pathogenic gene locus.


  • 주제어

    Parkinson Disease .   Vitamin D .   Receptors, Calcitriol .   Polymorphism, Genetic.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

유료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기