본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Concurrent Male Gynecomastia and Testicular Hydrocele after Imatinib Mesylate Treatment of a Gastrointestinal Stromal Tumor

Kim, Hawk    (Division of Hematology-Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Chang, Heung-Moon    (Division of Hematology-Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Ryu, Min-Hee    (Division of Hematology-Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Kim, Tae-Won    (Division of Hematology-Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Sohn, Hee-Jung    (Division of Hematology-Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Kim, So-Eun    (Division of Hematology-Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Kang, Hye-Jin    (Division of Hematology-Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Park, Sarah    (Division of Hematology-Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Lee, Jung-Shin    (Division of Hematology-Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Kang, Yoon-Koo    (D  );
  • 초록

    We report a gastrointestinal stromal tumor (GIST) patient with male gynecomastia and testicular hydrocele after treatment with imatinib mesylate. A 42 yr-old male patient presented for management of hepatic masses. Two years earlier, he had undergone a small bowel resection to remove an intraabdominal mass later shown to be a GIST, followed by adjuvant radiation therapy. At presentation, CT scan revealed multiple hepatic masses, which were compatible with metastatic GIST, and he was prescribed imatinib 400 mg/day. During treatment, he experienced painful enlargement of the left breast and scrotal swelling. Three months after cessation of imatinib treatment, the tumors recurred, and, upon recommencing imatinib, he experienced painful enlargement of the right breast and scrotal swelling. He was diagnosed with male gynecomastia caused by decreased testosterone and non-communicative testicular hydrocele. He was given androgen support and a hydrocelectomy, which improved his gynecomastia. The mechanism by which imatinib induces gynecomastia and hydrocele is thought to be associated with an inhibition of c-KIT and platelet-derive growth factor. This is the first report, to our knowledge, describing concurrent male gynecomastia and testicular hydrocele after imatinib treatment of a patient with GIST.


  • 주제어

    Gynecomastia .   Hydrocele .   imatinib .   Gastrointestinal Stromal Tumors.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

유료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기