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Comparison of the Clinical Features of Apical Hypertrophic Cardiomyopathy Versus Asymmetric Septal Hypertrophy in Korea

Yang, Hyun Suk    (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Song, Jae-Kwan    (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Song, Jong-Min    (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Kang, Duk-Hyun    (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Lee, Cheol Whan    (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Hong, Myeong-Ki    (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Kim, Jae-Joong    (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Park, Seong-Wook    (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.   ); Park, Seung-Jung    (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.  );
  • 초록

    Background We sought to test whether patients with apical hypertrophic cardiomyopathy (APH) have different clinical features compared to those with typical asymmetric septal hypertrophy (ASH). Methods Among 32,534 patients who underwent routine echocardiography at Asan Medical Center from January 2000 to December 2001, 305 patients (0.9%), who were finally diagnosed with hypertrophic cardiomyopathy (HCMP), were evaluated. The type of HCMP was classified according to the echocardiographic findings. Results ASH was the most frequent type (n=160, 53%, group I), and APH was the second most frequent (n=91, 30%, group II). Mean age (60.8±10 vs. 48.2±14 years, p p = 0.022) were significantly higher in group II than in group I. Family history of HCMP (4.4% vs. 0% p = 0.043) and sudden cardiac death (8.8% vs. 1.1% p = 0.014) was more prevalent in group I. During the follow-up period of 32.0± 37.2 months, cardiac events occurred at a significantly higher rate in group I (25.5% vs. 8.8%, p = 0.003). Conclusion APH comprises a significant proportion of HCMP in Korea and patients with APH show different clinical features compared to those with ASH.


  • 주제어

    Hypertrophic cardiomyopathy .   Prognosis .   Echocardiography.  

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