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Investigation of the Bovine Leukemia Virus Proviral DNA in Human Leukemias and Lung cancers in Korea

Lee, Jehoon    (Department of Clinical Pathology, The Catholic University of Korea, Medical College, Korea.   ); Kim, Yonggoo    (Department of Clinical Pathology, The Catholic University of Korea, Medical College, Korea.   ); Kang, Chang Suk    (Department of Clinical Pathology, The Catholic University of Korea, Medical College, Korea.   ); Cho, Dae Hyun    (Department of General Toxicology, National Institute of Toxicological Research, Seoul, Korea.   ); Shin, Dong Hwan    (Department of General Toxicology, National Institute of Toxicological Research, Seoul, Korea.   ); Yum, Young Na    (Department of General Toxicology, National Institute of Toxicological Research, Seoul, Korea.   ); Oh, Jae Ho    (Department of General Toxicology, National Institute of Toxicological Research, Seoul, Korea.   ); Kim, Sheen Hee    (Department of General Toxicology, National Institute of Toxicological Research, Seoul, Korea.   ); Hwang, Myung Sil    (Department of General Toxicology, National Institute of Toxicological Research, Seoul, Korea.   ); Lim, Chul Joo    (Department of General Toxicology, National Institute of Toxicological Research, Seoul, Korea.   ); Yang, Ki Hwa    (Department of General Toxicology, National Ins  ); Han, Kyungja  
  • 초록

    The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.


  • 주제어

    Leukemia .   Lung Neoplasms .   Leukemia Virus, Bovine .   Human Infection.  

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