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Polymorphism of Matrix Metalloproteinase-3 Promoter Gene as a Risk Factor for Coronary Artery Lesions in Kawasaki Disease

Park, Jeong-Ah    (Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.   ); Shin, Kyung-Sue    (Department of Pediatrics, Cheju National University College of Medicine, Jeju, Korea.   ); Kim, Youn Woo    (Department of Pediatrics, Cheju National University College of Medicine, Jeju, Korea.  );
  • 초록

    Kawasaki disease (KD) is a major cause of acquired coronary artery diseases in childhood. The serum levels of matrix metalloproteinase (MMP)-3 and MMP-9 in KD have been reported to be significantly higher than other diseases. Several studies have demonstrated that MMP-3 5A/6A polymorphism and MMP-9 C-1562T polymorphism modify each transcriptional activity in allele specific manner. We hypothesized that these polymorphisms may play a role as a risk factor for development of coronary artery lesions (CAL) in KD. Eighty-three patients, diagnosed with KD in Cheju National University Hospital from January 2000 to February 2004, were divided into two groups according to the presence of CAL. Genotyping of MMP-3 and MMP-9 gene polymorphisms were determined by restriction fragment length polymorphism. With regard to MMP-3 gene polymorphism, the KD with CAL group had a higher frequency of 6A/6A genotype than control group ( p = 0.0127) and the KD without CAL group ( p = 0.0036). However, no significant differences in the allele and genotype distributions of the MMP-9 polymorphism were observed. These findings suggest that MMP-3 6A/6A genotype may be an independent risk factor for CAL formation in KD.


  • 주제어

    Matrix Metalloproteinases .   Kawasaki Disease .   Mucocutaneous Lymph Node Syndrome .   Coronary Vessels .   Polymorphism, Genetic.  

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