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Epstein-Barr Virus and p16 INK4A Methylation in Squamous Cell Carcinoma and Precancerous Lesions of the Cervix Uteri

Kim, Na Rae    (Department of Pathology, Gachon Medical School Gil Medical Center, Incheon, Korea.   ); Lin, Zhenhua    (Department of Pathology, Guro Hospital, Korea University College of Medicine, Seoul, Korea.   ); Kim, Kyong Rae    (Department of Surgery, College of Medicine, Konkuk University, Chungju, Korea.   ); Cho, Hyun Yee    (Department of Pathology, Gachon Medical School Gil Medical Center, Incheon, Korea.   ); Kim, Insun    (Department of Pathology, Guro Hospital, Korea University College of Medicine, Seoul, Korea.  );
  • 초록

    Methylation of p16 is an important mechanism in cervical carcinogenesis. However, the relationship between cervical squamous cell carcinoma (SCC) and Epstein-Barr virus (EBV) remains controversial. Here, we explored whether EBV infection and/or p16 gene inactivation would play any role in cervical carcinogenesis. Eighty-two specimens included 41 invasive SCCs, 30 cervical intraepithelial neoplasm (CIN; CIN 1, 11 cases, CIN II, 3 cases, CIN III 16 cases) and 11 nonneoplastic cervices. EBV was detected by polymerase chain reaction (PCR) for EBNA-1 and in situ hybridization for EBER-1. The p16 methylation-status and the expression of p16 protein were studied by methylation-specific PCR and immunohistochemistry, respectively. The materials were divided into four groups: 1) nonneoplastic cervices, 2) CIN I, 3) CIN II-III and 4) invasive SCCs. p16 methylation and p16 immunoexpressions increased in CIN and invasive SCCs than nonneoplastic tissue. p16 -methylation and p16-immunoreactivities were higher in the EBV-positive group ( p = 0.009, p p16 methylation, p16 immunoreactivity and the detection of EBV strongly suggested that the cooperation of EBV and p16 gene may play a synergic effect on cell cycle deregulation.


  • 주제어

    Protein p16 .   Methylation .   Herpesvirus 4, Human .   Epstein-Barr Virus Infections .   Cervix Neoplasms .   Carcinogenesis.  

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