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Journal of veterinary science v.8 no.3, 2007년, pp.299 - 301  

Identification of single-nucleotide polymorphisms of the prion protein gene in sika deer ( Cervus nippon laiouanus )

Jeong, Hyun-Jeong    (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.   ); Lee, Joong-Bok    (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.   ); Park, Seung-Yong    (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.   ); Song, Chang-Seon    (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.   ); Kim, Bo-Sook    (Animal Research Division, Seoul Grand Park Zoo, Gwacheon 427-420, Korea.   ); Rho, Jung-Rae    (Animal Research Division, Seoul Grand Park Zoo, Gwacheon 427-420, Korea.   ); Yoo, Mi-Hyun    (Animal Research Division, Seoul Grand Park Zoo, Gwacheon 427-420, Korea.   ); Jeong, Byung-Hoon    (Ilsong Institute of Life Science, Hallym University, Anyang 431-060, Korea.   ); Kim, Yong-Sun    (Ilsong Institute of Life Science, Hallym University, Anyang 431-060, Korea.   ); Choi, In-Soo    (Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.  );
  • 초록

    Polymorphisms of the prion protein gene ( PRNP ) have been detected in several cervid species. In order to confirm the genetic variations, this study examined the DNA sequences of the PRNP obtained from 33 captive sika deer ( Cervus nippon laiouanus ) in Korea. A total of three single-nucleotide polymorphisms (SNPs) at codons 100, 136 and 226 in the PRNP of the sika deer were identified. The polymorphic site located at codon 100 has not been reported. The SNPs detected at codons 100 and 226 induced amino acid substitutions. The SNP at codon 136 was a silent mutation that does not induce any amino acid change. The genotype and allele frequencies were determined for each of the SNPs.


  • 주제어

    PRNP .   sika deer .   single-nucleotide polymorphism.  

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