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Journal of Korean medical science : JKMS v.25 no.7 = no.140, 2010년, pp.1066 - 1070   SCI SCIE SCOPUS
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Epithelial-Mesenchymal Transitions of Bile Duct Epithelial Cells in Primary Hepatolithiasis

Zhao, Lijin    (Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China.   ); Yang, Rigao    (Department of General Surgery, The 324th Hospital of PLA, Chongqing, China.   ); Cheng, Long    (Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China.   ); Wang, Maijian    (Affiliated Hospital of Zunyi Medical College, Zunyi, China.   ); Jiang, Yan    (Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China.   ); Wang, Shuguang    (Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, China.  );
  • 초록

    The purpose of this study was to explore the role of epithelial-mesenchymal transition in the pathogenesis of hepatolithiasis. Thirty-one patients with primary hepatolithiasis were enrolled in this study. Expressions of E-cadherin, α-catenin, α-SMA, vimentin, S100A4, TGF-β1 and P-smad2/3 in hepatolithiasis bile duct epithelial cells were examined by immunohistochemistry staining. The results showed that the expressions of the epithelial markers E-cadherin and α-catenin were frequently lost in hepatolithiasis (32.3% and 25.9% of cases, respectively), while the mesenchymal markers vimentin, α-SMA and S100A4 were found to be present in hepatolithiasis (35.5%, 29.0%, and 32.3% of cases, respectively). The increased mesenchymal marker expression was correlated with decreased epithelial marker expression. The expressions of TGF-β1 and P-smad2/3 in hepatolithiasis were correlated with the expression of S100A4. These data indicate that TGF-β1-mediated epithelial-mesenchymal transition might be involved in the formation of hepatolithiasis.


  • 주제어

    Epithelial-mesenchymal Transition .   Primary Hepatolithiasis .   Bile Duct Epithelial Cell .   Transforming Growth Factor beta1 .   Immunohistochemistry.  

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